Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia
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چکیده
منابع مشابه
Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy
Metaphyseal chondrodysplasia, Schmid type (MCDS) is characterized by mild short stature and growth plate hypertrophic zone expansion, and caused by collagen X mutations. We recently demonstrated the central importance of ER stress in the pathology of MCDS by recapitulating the disease phenotype by expressing misfolding forms of collagen X (Schmid) or thyroglobulin (Cog) in the hypertrophic zone...
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It is well known that sex steroids, in particular estrogens, play an important role in longitudinal bone growth during puberty. High doses of estrogen therapy can reduce the final height of an individual, but such treatment is also associated with severe side effects. At the same time, attenuation of estrogen production by aromatase inhibitors increases adult final height, inhibiting bone turno...
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OBJECTIVES The purpose of this study is to evaluate the effects of allogenic costal cartilage transplantation on preventing bony bridge formation and angular deformities for the treatment of partial growth plate injury using a rabbit model. METHODS An experimental model of partial growth injury was created by resecting the medial part of the proximal tibial growth plate in male six-week-old N...
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deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...
MEPE is a novel regulator of growth plate cartilage mineralization
Matrix extracellular phosphoglycoprotein (MEPE) belongs to the SIBLING protein family which play key roles in biomineralization. Although the growth plates of MEPE-overexpressing mice display severe morphological disruption, the expression and function of MEPE in growth plate matrix mineralization remains largely undefined. Here we show MEPE and its cleavage product, the acidic serine aspartate...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2018
ISSN: 1063-4584
DOI: 10.1016/j.joca.2018.07.015